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Cut Calories, Stave Off Age-Related Disease

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Cut Calories, Stave Off Age-Related Disease

Smaller portions could lower heart disease, diabetes risk

Make sure you’re healthy in your golden years by eating a little less every day. That’s what a new study from the U.S. National Institute on Aging (NIA) suggests.

The “results are quite intriguing,” study co-author Evan Hadley, M.D., director of geriatrics and clinical gerontology at the NIA, said in a release. “They show that this degree of sustained calorie restriction can influence disease risk factors and possible predictors of longevity in healthy, non-obese people.”

The researchers randomly assigned more than 200 healthy young or middle-aged adults to either a calorie restriction group or a control group that continued regular eating habits.

Earlier animal studies have shown calorie restriction—consuming fewer calories while still getting essential nutrients—extends longevity and slows the progression of many age-related diseases, according to researchers.

For this study, the participants in the calorie restriction group were given a target of 15.5 percent weight loss in the first year. To accomplish this, they had to reduce their calorie intake by 25 percent. They were asked to maintain their weight in the second year of the study.

In the study’s first year, the people in this group lost an average of 10 percent of their body weight; they maintained this weight loss over the second year. Even though they missed the weight loss goal, researchers said it was the largest sustained weight loss seen in any dietary trial in non-obese people. And though the average 12 percent reduction in calorie intake fell short of the 25 percent target, the participants maintained calorie restriction for the entire two years of the study.

The calorie restriction group showed significant improvements in several predictors of heart disease, including a 6 percent decrease in total cholesterol, a 4 percent reduction in blood pressure and increased levels of good (HDL) cholesterol. They also had a 47 percent decrease in levels of C-reactive protein, a marker of inflammation linked to heart disease, and reduced insulin resistance, a risk factor for diabetes. And levels of a marker of thyroid activity fell by more than 20 percent. This may be telling because some studies have suggested lower thyroid activity may be associated with longevity.

All of the study results weren’t great, however. Some of the people in the calorie restriction group developed temporary anemia, and some experienced larger-than-expected decreases in bone density. The study authors say these findings highlight the need for medical monitoring during calorie restriction.

Dr. Hadley said more research is needed to see if calorie restriction offers additional long-term benefits.

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BHM Edit Staff